Needle ins pos#2, 40/42 Pilot, 172/175 main.. That should get you in the ball park. Depending on temps/alt/fuels etc you may find you need to make some further adjustments, but probably won't be too far off.
I'd actually also reccomend a NEDW needle, or N3CW (Yamaha), as the 250's prefer to run a tad richer on the needle diamter.