I'll chime in here since I've owned every size Gasgas 2-stroke as well as a WR250f and now a KTM 450exc.
In regards to the Gasgas 2-strokes; each can be ridden by "heavier" riders without issue. I weigh around 215 and have no issues on the 200, 250, or 300 when it comes to lugging or climbing up nasty steep terrain. The differences is in how you get up and over the obstacles. The 200 takes more rpms and more clutch work than the 250 or 300. The 200 Gasgas lugs incredibly well for a small cc bike and I never found anything it couldn't climb, but it does need to be in proper rpms and some clutch work. Check out some of Liv2days's videos and watch him conquer some good climbs on his 200.
As mentioned, correct gearing and jetting are essential on the 200. 13/50 or 13/52 is needed to utilize the lower rpm power on the 200 and good solid jetting, as suggested on this site let's the bike run properly giving it the ability to run well at those lower rpms.
The 250 is a fantastic bike that can lug with the best of them or sing on the pipe. It's all in the set up and if jetted properly will lug down like a 300 and climb anything you throw at it with ease.
The 300 is just the ultimate lug with ease bike. Throw it in 3rd gear and let it climb anything without effort. The 300 takes the least amount of rider input.
The 250f is a super fun format for flat, flowing trails. It can slice and dice very well. But, it's not great climber and 250f's are the most risky used bike to buy as mentioned before with not great long term reliability.
A 450 is a completely different animal and very dependent on year, make and model of bike. Buying a WR 450 or a RFS KTM and lug all day without issue and put 20,000 miles in it with steady oil changes and clean air flowing.
Obviously, the newer the bike, usually the better, but I've always looked for older, low hour bikes and have had great success. Gasgas, especially has unreal reliability and they just keep going and are very durable.
Hope this helps.
BTW, the 200 Gasgas is the most fun bike I've ever owned. The handling combined with good stability and great motor are a fantastic combination. I think I was fastest on the EC200.
But, the 300 Gasgas is the easiest bike I've ever ridden. It has an amazing motor that takes so little input. That, combined with great handling make it so easy to ride.