I bought my first 2 stroke in 2010/11 and had no idea. It was a steep learning curve. Lots of reading, followed by lots of trial and error. Lot's of stopping trail side to make adjustments, and lots of chasing myself in circles.
Since that bike, I have learnt it's easier to simply take the time up front to make sure everything is good before even riding it.
For me that means bike comes apart. Carb gets pulled, fuel height checked, cap screws replaced, throttle cable changed to one with captive ends, slide inspected and manually set while viewing its position through the body. Needle of my choice gets fitted as a baseline with known pilot and main jets.
Head gets measured, squished, modified back into a tighter tolerance at a specific compression ratio.
Straight up a I have removed a lot of variables, and with everything in it's ideal range to start with it's often a couple small adjustments and then many hours riding.