Hey Ando,
This isn't really something new to me. I went through it all with the 300 too running all the needle diameters from F through to J with many combinations of pilots, looking for the perfect balance of off idle response and cleanliness. I settled on the 42P and the J diameter.
Like you, my general focus is also on the needle clip position as this is where I like to ride when the trail allows, however a lot of my riding is mixed including technical 1st/2nd gear climbing and log hopping and its here where this focus is coming from. The 300 preferred a leaner needle diameter, and a clip position leaner on the needle, and at this point 2 sizes leaner on the main as well.
Don't be turned off the idea of the 250. Its so much more fun to ride and just sings as you smash the throttle through the trees. The engine makes pleanty of power in the meat of the band which is quite well spread through the rpm. Its definately softer off the bottom which is expected and which was mostly why I went to the 250. There is still heaps of bottom end torque to be found on the 250 too, its just requiring a bit more fuel to get it just right. In all honesty I found the same with the 300 where a richer needle diameter would give better response off the bottom, but preffered the leaner needle which gave a smoother transition onto the needle. The 300 had more than enough torque to be able to open the throttle and rip the gear high.
Realistically though its not very surprising that the 2 engines have different fuelling requirements. The 250 runs significantly more compression than the 300 and the smaller capacity always had me thinking it would require larger jets and possibly needle clip position. What I have determined is that N3Ex#3 is too rich for my liking, N3Ex#2 is too lean and lacks the torque on the needle to pull a gear high under load. N3Cx#3 is right on the money. Colours the plugs up nicely and rips along on the needle. The 178 main feels pretty close and I am happy to have it a tad rich while dialling everything in. Its just a matter of getting the pilot response strong without excessive burbling. 40/H isn't far off. 42/J is close on the leaner side. I had tried a 45 but it caused a burble that didn't clear up as earlier as I'd like and I ended up more than 2.5 turns out on the AS. The W will be right on!